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In Vitro Synergistic Effect of Psidium guineense (Swartz) in Combination with Antimicrobial Agents against Methicillin-Resistant Staphylococcus aureus Strains
Joint Authors
Fernandes, Tiago Gomes
de Mesquita, Amanda Rafaela Carneiro
Franchitti, Adelisa Alves
Randau, Karina Perrelli
Ximenes, Eulália Azevedo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The aim of this study was to evaluate the antimicrobial activity of aqueous extract of Psidium guineense Swartz (Araçá-do-campo) and five antimicrobials (ampicillin, amoxicillin/clavulanic acid, cefoxitin, ciprofloxacin, and meropenem) against twelve strains of Staphylococcus aureus with a resistant phenotype previously determined by the disk diffusion method.
Four S.
aureus strains showed resistance to all antimicrobial agents tested and were selected for the study of the interaction between aqueous extract of P.
guineense and antimicrobial agents, by the checkerboard method.
The criteria used to evaluate the synergistic activity were defined by the fractional inhibitory concentration index (FICI).
All S.
aureus strains were susceptible to P.
guineense as determined by the microdilution method.
The combination of the P.
guineense extract with the antimicrobial agents resulted in an eight-fold reduction in the MIC of these agents, which showed a FICI ranging from 0.125 to 0.5, suggesting a synergistic interaction against methicillin-resistant Staphylococcus aureus (MRSA) strains.
The combination of the aqueous extract of P.
guineense with cefoxitin showed the lowest FICI values.
This study demonstrated that the aqueous extract of P.
guineense combined with beta lactamics antimicrobials, fluoroquinolones, and carbapenems, acts synergistically by inhibiting MRSA strains.
American Psychological Association (APA)
Fernandes, Tiago Gomes& de Mesquita, Amanda Rafaela Carneiro& Randau, Karina Perrelli& Franchitti, Adelisa Alves& Ximenes, Eulália Azevedo. 2012. In Vitro Synergistic Effect of Psidium guineense (Swartz) in Combination with Antimicrobial Agents against Methicillin-Resistant Staphylococcus aureus Strains. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-450460
Modern Language Association (MLA)
Fernandes, Tiago Gomes…[et al.]. In Vitro Synergistic Effect of Psidium guineense (Swartz) in Combination with Antimicrobial Agents against Methicillin-Resistant Staphylococcus aureus Strains. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-450460
American Medical Association (AMA)
Fernandes, Tiago Gomes& de Mesquita, Amanda Rafaela Carneiro& Randau, Karina Perrelli& Franchitti, Adelisa Alves& Ximenes, Eulália Azevedo. In Vitro Synergistic Effect of Psidium guineense (Swartz) in Combination with Antimicrobial Agents against Methicillin-Resistant Staphylococcus aureus Strains. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-450460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450460