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Skin Needling to Enhance Depigmenting Serum Penetration in the Treatment of Melasma
Joint Authors
Annunziata, M. C.
De Vita, Valerio
Fardella, N.
Fabbrocini, Gabriella
Cameli, N.
Mauriello, Maria Chiara
Monfrecola, Ambra
Pastore, F.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Melasma is a common hypermelanotic disorder affecting the facial area which has a considerable psychological impact on the patient.
Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents, such as rucinol and sophora-alpha.
Aims.
We aim to compare the combined treatment of skin needling and depigmenting serum with that using depigmenting serum alone in the treatment of melasma, in order to evaluate the use of microneedles as a means to enhance the drug’s transdermal penetration.
Methods.
Twenty patients were treated with combined skin needling and depigmenting serum on one side of the face and with depigmenting serum alone on the other side.
The outcome was evaluated periodically for up to two months using the Melasma Area Severity Index score and the Spectrocolorimeter X-Rite 968.
Results.
The side with combined treatment (skin needling + depigmenting serum) presented a statistically significant reduction in MASI score and luminosity index (L) levels compared to the side treated with depigmenting serum alone, and clinical symptoms were significantly improved.
Conclusions.
Our study suggests the potential use of combining skin needling with rucinol and sophora-alpha compounds to achieve better results in melasma treatment compared to rucinol and sophora-alpha alone.
American Psychological Association (APA)
Fabbrocini, Gabriella& De Vita, Valerio& Fardella, N.& Pastore, F.& Annunziata, M. C.& Mauriello, Maria Chiara…[et al.]. 2011. Skin Needling to Enhance Depigmenting Serum Penetration in the Treatment of Melasma. Plastic Surgery International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-450461
Modern Language Association (MLA)
Fabbrocini, Gabriella…[et al.]. Skin Needling to Enhance Depigmenting Serum Penetration in the Treatment of Melasma. Plastic Surgery International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-450461
American Medical Association (AMA)
Fabbrocini, Gabriella& De Vita, Valerio& Fardella, N.& Pastore, F.& Annunziata, M. C.& Mauriello, Maria Chiara…[et al.]. Skin Needling to Enhance Depigmenting Serum Penetration in the Treatment of Melasma. Plastic Surgery International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-450461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450461