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Age-Related Loss of Muscle Mass and Strength
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Age-related muscle wasting and increased frailty are major socioeconomic as well as medical problems.
In the quest to extend quality of life it is important to increase the strength of elderly people sufficiently so they can carry out everyday tasks and to prevent them falling and breaking bones that are brittle due to osteoporosis.
Muscles generate the mechanical strain that contributes to the maintenance of other musculoskeletal tissues, and a vicious circle is established as muscle loss results in bone loss and weakening of tendons.
Molecular and proteomic approaches now provide strategies for preventing age-related muscle wasting.
Here, attention is paid to the role of the GH/IGF-1 axis and the special role of the IGFI-Ec (mechano growth factor/MGF) which is derived from the IGF-I gene by alternative splicing.
During aging MGF levels decline but when administered MGF activates the muscle satellite (stem) cells that “kick start” local muscle repair and induces hypertrophy.
American Psychological Association (APA)
Goldspink, Geoffrey. 2012. Age-Related Loss of Muscle Mass and Strength. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-450464
Modern Language Association (MLA)
Goldspink, Geoffrey. Age-Related Loss of Muscle Mass and Strength. Journal of Aging Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-450464
American Medical Association (AMA)
Goldspink, Geoffrey. Age-Related Loss of Muscle Mass and Strength. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-450464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450464