Circulating Cytokine Profiles and Their Relationships with Autoantibodies, Acute Phase Reactants, and Disease Activity in Patients with Rheumatoid Arthritis
Joint Authors
Ally, Mahmood
Meyer, Pieter W. A.
Wadee, Ahmed A.
Fickl, Heidi
Hodkinson, Bridget
Musenge, Eustasius
Anderson, Ronald
Tikly, Mohammed
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Our objective was to analyse the relationship between circulating cytokines, autoantibodies, acute phase reactants, and disease activity in DMARDs-naïve rheumatoid arthritis (RA) patients (n=140).
All cytokines were significantly higher in the RA cohort than in healthy controls.
Moderate-to-strong positive intercorrelations were observed between Th1/Th2/macrophage/fibroblast-derived cytokines.
RF correlated significantly with IL-1β, IL-2, IL-4, IL-10, IL-12, G-CSF, GM-CSF, IFN-γ, and TNF (P<.0001), and aCCP and aMCV with IL-1β, IL-2, IL-4, and IL-10 (P<.0002), while IL-6 correlated best with the acute phase reactants, CRP, and SAA (P<.0001).
In patients with a DAS28 score of ≥5.1, IFN-γ, IL-1β, IL-1Ra, TNF, GM-CSF, and VEGF were significantly correlated (P<.04–.001) with high disease activity (HDA).
Circulating cytokines in RA reflect a multifaceted increase in immune reactivity encompassing Th1 and Th2 cells, monocytes/macrophages, and synovial fibroblasts, underscored by strong correlations between these cytokines, as well as their relationships with RF, aCCP, and aMCV, with some cytokines showing promise as biomarkers of HDA.
American Psychological Association (APA)
Meyer, Pieter W. A.& Hodkinson, Bridget& Ally, Mahmood& Musenge, Eustasius& Wadee, Ahmed A.& Fickl, Heidi…[et al.]. 2011. Circulating Cytokine Profiles and Their Relationships with Autoantibodies, Acute Phase Reactants, and Disease Activity in Patients with Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-450486
Modern Language Association (MLA)
Meyer, Pieter W. A.…[et al.]. Circulating Cytokine Profiles and Their Relationships with Autoantibodies, Acute Phase Reactants, and Disease Activity in Patients with Rheumatoid Arthritis. Mediators of Inflammation No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-450486
American Medical Association (AMA)
Meyer, Pieter W. A.& Hodkinson, Bridget& Ally, Mahmood& Musenge, Eustasius& Wadee, Ahmed A.& Fickl, Heidi…[et al.]. Circulating Cytokine Profiles and Their Relationships with Autoantibodies, Acute Phase Reactants, and Disease Activity in Patients with Rheumatoid Arthritis. Mediators of Inflammation. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-450486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450486