Tobacco Exposure by Various Modes May Alter Proinflammatory (IL-12) and Anti-Inflammatory (IL-10) Levels and Affects the Survival of Prostate Carcinoma Patients : An Explorative Study in North Indian Population
Joint Authors
Mandhani, Anil
Khattri, Sanjay
Sharma, Praveen
Pant, Kamlesh Kumar
Dwivedi, Shailendra
Goel, Apul
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Inflammation is an important hallmark of all cancers and net inflammatory response is determined by a delicate balance between pro- and anti-inflammatory cytokines, which may be affected by tobacco exposure, so the present study was designed to explore the effect of various modes of tobacco exposure on interleukin-12 (IL-12) and interleukin-10 (IL-10) inflammatory cytokine levels and survival in prostate carcinoma (PCa) patients.
Methods.
285 cancer patients and equal controls with 94 BPH (benign prostatic hyperplasia) were recruited; baseline levels of serum IL-12 and IL-10 were measured and analyzed in various tobacco exposed groups by appropriate statistical tool.
Five-year survivals of patients were analyzed by Log-rank (Mantel-Cox) test (graph pad version 5).
Results.
The expression of serum proinflammatory (IL-12) and anti-inflammatory (IL-10) cytokines was correlated with tobacco exposed group as smokers, chewers, and alcohol users have shown significantly higher levels (P<0.001) with significantly lower median survivals (27.1 months, standard error = 2.86, and 95% CI: 21.4–32.62); than nonusers.
Stages III and IV of tobacco addicted patients have also shown significantly increased levels of IL-12 and IL-10.
Conclusions.
IL-12 and IL-10 seem to be affected by various modes of tobacco exposure and inflammation also affects median survival of cancer patients.
American Psychological Association (APA)
Dwivedi, Shailendra& Goel, Apul& Khattri, Sanjay& Mandhani, Anil& Sharma, Praveen& Pant, Kamlesh Kumar. 2014. Tobacco Exposure by Various Modes May Alter Proinflammatory (IL-12) and Anti-Inflammatory (IL-10) Levels and Affects the Survival of Prostate Carcinoma Patients : An Explorative Study in North Indian Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-450489
Modern Language Association (MLA)
Dwivedi, Shailendra…[et al.]. Tobacco Exposure by Various Modes May Alter Proinflammatory (IL-12) and Anti-Inflammatory (IL-10) Levels and Affects the Survival of Prostate Carcinoma Patients : An Explorative Study in North Indian Population. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-450489
American Medical Association (AMA)
Dwivedi, Shailendra& Goel, Apul& Khattri, Sanjay& Mandhani, Anil& Sharma, Praveen& Pant, Kamlesh Kumar. Tobacco Exposure by Various Modes May Alter Proinflammatory (IL-12) and Anti-Inflammatory (IL-10) Levels and Affects the Survival of Prostate Carcinoma Patients : An Explorative Study in North Indian Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-450489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450489