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Molecular Bases of Cutaneous and Uveal Melanomas
Joint Authors
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Intensive research in recent years has begun to unlock the mysteries surrounding the molecular pathogenesis of melanoma, the deadliest of skin cancers.
The high-penetrance, low-frequency susceptibility gene CDKN2A produces tumor suppressor proteins that function in concert with p53 and retinoblastoma protein to thwart melanomagenesis.
Aberrant CDKN2A gene products have been implicated in a great many cases of familial cutaneous melanoma.
Sporadic cases, on the other hand, often involve constitutive signal transduction along the mitogen-activated protein kinase (MAPK) pathway, with particular focus falling upon mutated RAS and RAF protooncogenes.
The proliferative effects of the MAPK pathway may be complemented by the antiapoptotic signals of the PI3K/AKT pathway.
After skin, melanoma most commonly affects the eye.
Data for the constitutive activation of the MAPK pathway in uveal melanoma exists as well, however, not through mutations of RAS and RAF.
Rather, evidence implicates the proto-oncogene GNAQ.
In the following discussion, we review the major molecular pathways implicated in both familial and sporadic cutaneous melanomagenesis, the former accounting for approximately 10% of cases.
Additionally, we discuss the molecular pathways for which preliminary evidence suggests a role in uveal melanomagenesis.
American Psychological Association (APA)
Gaudi, Sudeep& Messina, Jane L.. 2011. Molecular Bases of Cutaneous and Uveal Melanomas. Pathology Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-450565
Modern Language Association (MLA)
Gaudi, Sudeep& Messina, Jane L.. Molecular Bases of Cutaneous and Uveal Melanomas. Pathology Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-450565
American Medical Association (AMA)
Gaudi, Sudeep& Messina, Jane L.. Molecular Bases of Cutaneous and Uveal Melanomas. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-450565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450565