Serum Soluble TACI, a BLyS Receptor, Is a Powerful Prognostic Marker of Outcome in Chronic Lymphocytic Leukemia
Joint Authors
Panayiotidis, Panayiotis P.
Maltezas, Dimitrios
Tzenou, Tatiana
Pangalis, Gerassimos A.
Bartzis, Vassiliki
Sarris, Katerina
Angelopoulou, Maria K.
Dimou, Maria
Nikolaou, Eftychia
Viniou, Nora A.
Sfikakis, Petros P.
Koulieris, Efstathios
Kalpadakis, Christina
Kyrtsonis, Marie-Christine
Siakandaris, Mariana P.
Sachanas, Sotirios
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
BLyS is involved in CLL biology and its low soluble serum levels related to a shorter time to first treatment (TFT).
TACI is a BLyS receptor and can be shed from cells’ surface and circulate in soluble form (sTACI).
We investigated the impact of serum BLyS and sTACI levels at diagnosis in CLL patients and their relationship with disease parameters and patients’ outcome.
Serum BLyS was determined in 73 patients, while sTACI in 60.
Frozen sera drawn at diagnosis were tested by ELISA.
sTACI concentrations correlated with BLyS (P=-0.000021), b2-microglobulin (P=0.005), anemia (P=-0.03), thrombocytopenia (P=0.04), Binet stage (P=0.02), and free light chains ratio (P=0.0003).
Soluble BLyS levels below median and sTACI values above median were related to shorter TFT (P=0.0003 and 0.007).
During a ten-year followup, sTACI levels, but not BLyS, correlated with survival (P=0.048).
In conclusion, we confirmed the prognostic significance of soluble BLyS levels with regard to TFT in CLL patients, and, more importantly, we showed for the first time that sTACI is a powerful prognostic marker, related to parameters of disease activity and staging and, more importantly, to TFT and OS.
American Psychological Association (APA)
Kyrtsonis, Marie-Christine& Sarris, Katerina& Koulieris, Efstathios& Maltezas, Dimitrios& Nikolaou, Eftychia& Angelopoulou, Maria K.…[et al.]. 2014. Serum Soluble TACI, a BLyS Receptor, Is a Powerful Prognostic Marker of Outcome in Chronic Lymphocytic Leukemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-450594
Modern Language Association (MLA)
Kyrtsonis, Marie-Christine…[et al.]. Serum Soluble TACI, a BLyS Receptor, Is a Powerful Prognostic Marker of Outcome in Chronic Lymphocytic Leukemia. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-450594
American Medical Association (AMA)
Kyrtsonis, Marie-Christine& Sarris, Katerina& Koulieris, Efstathios& Maltezas, Dimitrios& Nikolaou, Eftychia& Angelopoulou, Maria K.…[et al.]. Serum Soluble TACI, a BLyS Receptor, Is a Powerful Prognostic Marker of Outcome in Chronic Lymphocytic Leukemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-450594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450594