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Kinetic and Reaction Pathway Analysis in the Application of Botulinum Toxin A for Wound Healing
Joint Authors
Adler, Michael
Lebeda, Frank J.
Dembek, Zygmunt F.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
A relatively new approach in the treatment of specific wounds in animal models and in patients with type A botulinum toxin is the focus of this paper.
The indications or conditions include traumatic wounds (experimental and clinical), surgical (incision) wounds, and wounds such as fissures and ulcers that are signs/symptoms of disease or other processes.
An objective was to conduct systematic literature searches and take note of the reactions involved in the healing process and identify corresponding pharmacokinetic data.
From several case reports, we developed a qualitative model of how botulinum toxin disrupts the vicious cycle of muscle spasm, pain, inflammation, decreased blood flow, and ischemia.
We transformed this model into a minimal kinetic scheme for healing chronic wounds.
The model helped us to estimate the rate of decline of this toxin's therapeutic effect by calculating the rate of recurrence of clinical symptoms after a wound-healing treatment with this neurotoxin.
American Psychological Association (APA)
Lebeda, Frank J.& Dembek, Zygmunt F.& Adler, Michael. 2011. Kinetic and Reaction Pathway Analysis in the Application of Botulinum Toxin A for Wound Healing. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450605
Modern Language Association (MLA)
Lebeda, Frank J.…[et al.]. Kinetic and Reaction Pathway Analysis in the Application of Botulinum Toxin A for Wound Healing. Journal of Toxicology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450605
American Medical Association (AMA)
Lebeda, Frank J.& Dembek, Zygmunt F.& Adler, Michael. Kinetic and Reaction Pathway Analysis in the Application of Botulinum Toxin A for Wound Healing. Journal of Toxicology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450605