Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection : A Preliminary Study with MicroPET
Joint Authors
Zhu, Zhaohui
Cheng, Wuying
Xing, Haiqun
Li, Fang
Dang, Yonghong
Wu, Chenxi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Brown adipose tissue (BAT) is emerging as a potential target for treating human obesity.
It has been indicated that BAT is rich in innervations of sympathetic nerve control.
Using 18F-FDG microPET imaging, this study aims at evaluating how factors related to sympathetic activation/inhibition changed BAT metabolism of mice.
BAT 18F-FDG uptake were semiquantitatively evaluated in different groups of mice under temperature (cold or warm stimulus) or pharmacological interventions (norepinephrine, epinephrine, isoprenaline, or propranolol) and were compared with the corresponding controls.
It was found that BAT activation can be stimulated by cold exposure (P=1.96×10−4), norepinephrine (P=.002), or both (P=2.19×10−6) within an hour before 18F-FDG injection and can also be alleviated by warming up (P=.001) or propranolol lavage (P=.027).
This preliminary study indicated that BAT function could be evaluated by 18F-FDG PET imaging through short-term interventions, which paved the way for further investigation of the relationship between human obesity and BAT dysfunction.
American Psychological Association (APA)
Wu, Chenxi& Cheng, Wuying& Xing, Haiqun& Dang, Yonghong& Li, Fang& Zhu, Zhaohui. 2011. Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection : A Preliminary Study with MicroPET. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-450613
Modern Language Association (MLA)
Wu, Chenxi…[et al.]. Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection : A Preliminary Study with MicroPET. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-450613
American Medical Association (AMA)
Wu, Chenxi& Cheng, Wuying& Xing, Haiqun& Dang, Yonghong& Li, Fang& Zhu, Zhaohui. Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection : A Preliminary Study with MicroPET. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-450613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450613