Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts
Joint Authors
Zheng, Luyu
Tang, Yuping
Zhang, Xu
Wang, Ming-yan
Chen, Meijuan
Cheng, Ge
Dai, Xiaoming
Jiang, Miao
Zhou, Jing
Zhang, Huarong
Zhang, Weiyi
Yu, Yang
Yu, Wei
Xiong, Fei
Fu, Haian
Duan, Jinao
Jiang, Ming
Lin, Biaoyang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Many traditional Chinese medicine (TCM) formulae have been used in cancer therapy.
The JIN formula is an ancient herbal formula recorded in the classic TCM book Jin Kui Yao Lue (Golden Chamber).
The JIN formula significantly delayed the growth of subcutaneous human H460 xenografted tumors in vivo compared with the growth of mock controls.
Gene array analysis of signal transduction in cancer showed that the JIN formula acted on multiple targets such as the mitogen-activated protein kinase, hedgehog, and Wnt signaling pathways.
The coformula treatment of JIN and diamminedichloroplatinum (DDP) affected the stress/heat shock pathway.
Proteomic analysis showed 36 and 84 differentially expressed proteins between the mock and DDP groups and between the mock and JIN groups, respectively.
GoMiner analysis revealed that the differentially expressed proteins between the JIN and mock groups were enriched during cellular metabolic processes, and so forth.
The ones between the DDP and mock groups were enriched during protein-DNA complex assembly, and so forth.
Most downregulated proteins in the JIN group were heat shock proteins (HSPs) such as HSP90AA1 and HSPA1B, which could be used as markers to monitor responses to the JIN formula therapy.
The mechanism of action of the JIN formula on HSP proteins warrants further investigation.
American Psychological Association (APA)
Zheng, Luyu& Zhang, Weiyi& Jiang, Miao& Zhang, Huarong& Xiong, Fei& Yu, Yang…[et al.]. 2013. Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-450628
Modern Language Association (MLA)
Zheng, Luyu…[et al.]. Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-450628
American Medical Association (AMA)
Zheng, Luyu& Zhang, Weiyi& Jiang, Miao& Zhang, Huarong& Xiong, Fei& Yu, Yang…[et al.]. Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-450628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450628