Changes in Cytokines of the Bone Microenvironment during Breast Cancer Metastasis
Joint Authors
Sosnoski, Donna M.
Kraemer, William J.
Krishnan, Venkatesh
Dunn-Lewis, Courtenay
Mastro, Andrea M.
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It is commonly accepted that cancer cells interact with host cells to create a microenvironment favoring malignant colonization.
The complex bone microenvironment produces an ever changing array of cytokines and growth factors.
In this study, we examined levels of MCP-1, IL-6, KC, MIP-2, VEGF, MIG, and eotaxin in femurs of athymic nude mice inoculated via intracardiac injection with MDA-MB-231GFP human metastatic breast cancer cells, MDA-MB-231BRMS1GFP, a metastasis suppressed variant, or PBS.
Animals were euthanized (day 3, 11, 19, 27 after injection) to examine femoral cytokine levels at various stages of cancer cell colonization.
The epiphysis contained significantly more cytokines than the diaphysis except for MIG which was similar throughout the bone.
Variation among femurs was evident within all groups.
By day 27, MCP-1, MIG, VEGF and eotaxin levels were significantly greater in femurs of cancer cell-inoculated mice.
These pro-osteoclastic and angiogenic cytokines may manipulate the bone microenvironment to enhance cancer cell colonization.
American Psychological Association (APA)
Sosnoski, Donna M.& Krishnan, Venkatesh& Kraemer, William J.& Dunn-Lewis, Courtenay& Mastro, Andrea M.. 2012. Changes in Cytokines of the Bone Microenvironment during Breast Cancer Metastasis. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450636
Modern Language Association (MLA)
Sosnoski, Donna M.…[et al.]. Changes in Cytokines of the Bone Microenvironment during Breast Cancer Metastasis. International Journal of Breast Cancer No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450636
American Medical Association (AMA)
Sosnoski, Donna M.& Krishnan, Venkatesh& Kraemer, William J.& Dunn-Lewis, Courtenay& Mastro, Andrea M.. Changes in Cytokines of the Bone Microenvironment during Breast Cancer Metastasis. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450636