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Cost-Effectiveness Evaluation of Etoricoxib versus Celecoxib and Nonselective NSAIDs in the Treatment of Ankylosing Spondylitis in Norway
Joint Authors
Jansen, Jeroen P.
Taylor, Stephanie D.
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objectives.
To evaluate the cost-effectiveness of etoricoxib (90 mg) relative to celecoxib (200/400 mg), and the nonselective NSAIDs naproxen (1000 mg) and diclofenac (150 mg) in the initial treatment of ankylosing spondylitis in Norway.
Methods.
A previously developed Markov state-transition model was used to estimate costs and benefits associated with initiating treatment with the different competing NSAIDs.
Efficacy, gastrointestinal and cardiovascular safety, and resource use data were obtained from the literature.
Data from different studies were synthesized and translated into direct costs and quality adjusted life years by means of a Bayesian comprehensive decision modeling approach.
Results.
Over a 30-year time horizon, etoricoxib is associated with about 0.4 more quality adjusted life years than the other interventions.
At 1 year, naproxen is the most cost-saving strategy.
However, etoricoxib is cost and quality adjusted life year saving relative to celecoxib, as well as diclofenac and naproxen after 5 years of follow-up.
For a willingness-to-pay ceiling ratio of 200,000 Norwegian krones per quality adjusted life year, there is a >95% probability that etoricoxib is the most-cost-effective treatment when a time horizon of 5 or more years is considered.
Conclusions.
Etoricoxib is the most cost-effective NSAID for initiating treatment of ankylosing spondylitis in Norway.
American Psychological Association (APA)
Jansen, Jeroen P.& Taylor, Stephanie D.. 2011. Cost-Effectiveness Evaluation of Etoricoxib versus Celecoxib and Nonselective NSAIDs in the Treatment of Ankylosing Spondylitis in Norway. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-450643
Modern Language Association (MLA)
Jansen, Jeroen P.& Taylor, Stephanie D.. Cost-Effectiveness Evaluation of Etoricoxib versus Celecoxib and Nonselective NSAIDs in the Treatment of Ankylosing Spondylitis in Norway. International Journal of Rheumatology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-450643
American Medical Association (AMA)
Jansen, Jeroen P.& Taylor, Stephanie D.. Cost-Effectiveness Evaluation of Etoricoxib versus Celecoxib and Nonselective NSAIDs in the Treatment of Ankylosing Spondylitis in Norway. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-450643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450643