The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren's Syndrome
Joint Authors
Xiao, Lan
Cheng, Qian
Chen, Qian-ming
An, Shu
Wang, Yating
Lei, Lei
Jiang, Chun-miao
Wang, Jun
Huang, Yi-fan
Yu, Wen-jing
Gou, Yong-chao
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Sjogren's syndrome (SS) is a systemic, autoimmune disorder characterized by salivary insufficiency and lymphocytic infiltration of the exocrine glands.
Even though the mechanism of its pathology and progression has been researched ever since its discovery, the roles of different parts of immune system remain inconclusive.
There is no straightforward and simple theory for the pathogenesis and diagnosis of Sjogren’s syndrome because of the multiple kinds and functions of autoantibodies, changing proportion of different T-lymphocyte subsets with the progression of disease, unsuspected abilities of B lymphocytes discovered recently, crosstalk between cytokines connecting the factors mentioned previously, and genetic predisposition that contributes to the initiation of this disease.
On the other hand, the number of significant reports and open-label studies of B-cell depletion therapy showing clinical efficacy in sjogren’s syndrome has continued to accumulate, which provides a promising future for the patients.
In a word, further elucidation of the role of different components of the immune system will open avenues for better diagnosis and treatment of SS, whose current management is still mainly supportive.
American Psychological Association (APA)
Huang, Yi-fan& Cheng, Qian& Jiang, Chun-miao& An, Shu& Xiao, Lan& Gou, Yong-chao…[et al.]. 2013. The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren's Syndrome. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450661
Modern Language Association (MLA)
Huang, Yi-fan…[et al.]. The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren's Syndrome. Clinical and Developmental Immunology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-450661
American Medical Association (AMA)
Huang, Yi-fan& Cheng, Qian& Jiang, Chun-miao& An, Shu& Xiao, Lan& Gou, Yong-chao…[et al.]. The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren's Syndrome. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450661