The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy
Joint Authors
Kanasaki, Keizo
Xu, Yong
Huang, Wei
Gao, Chenlin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is a common and characteristic microvascular complication of diabetes; the mechanisms that cause DN have not been clarified, and the epigenetic mechanism was promised in the pathology of DN.
Furthermore, ubiquitination and small ubiquitin-like modifier (SUMO) were involved in the progression of DN.
MG132, as a ubiquitin proteasome, could improve renal injury by regulating several signaling pathways, such as NF-κB, TGF-β, Nrf2-oxidative stress, and MAPK.
In this review, we summarize how ubiquitination and sumoylation may contribute to the pathology of DN, which may be a potential treatment strategy of DN.
American Psychological Association (APA)
Gao, Chenlin& Huang, Wei& Kanasaki, Keizo& Xu, Yong. 2014. The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-450684
Modern Language Association (MLA)
Gao, Chenlin…[et al.]. The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-450684
American Medical Association (AMA)
Gao, Chenlin& Huang, Wei& Kanasaki, Keizo& Xu, Yong. The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-450684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450684