Effects of Polyethylene Glycol Spacer Length and Ligand Density on Folate Receptor Targeting of Liposomal Doxorubicin In Vitro
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The folate receptor is an attractive target for selective tumor delivery of liposomal doxorubicin (DXR) because it is abundantly expressed in a large percentage of tumors.
This study examined the effect of polyethylene glycol (PEG) spacer length and folate ligand density on the targeting ability of folate-modified liposomes.
Liposomes were modified with folate-derivatized PEG-distearoylphosphatidylethanolamine with PEG molecular weights of 2000, 3400, or 5000.
The association of DXR-loaded liposomes with KB cells, which overexpress the folate receptor, was evaluated by flow cytometry at various ratios of folate modification.
A low ratio of folate modification with a sufficiently long PEG chain showed the highest folate receptor-mediated association with the cells, but did not show the highest in vitro cytotoxicity.
DXR release from folate-modified liposomes in endosomes might be different.
These findings will be useful for designing folate receptor-targeting carriers.
American Psychological Association (APA)
Kawano, Kumi& Maitani, Yoshie. 2010. Effects of Polyethylene Glycol Spacer Length and Ligand Density on Folate Receptor Targeting of Liposomal Doxorubicin In Vitro. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-450712
Modern Language Association (MLA)
Kawano, Kumi& Maitani, Yoshie. Effects of Polyethylene Glycol Spacer Length and Ligand Density on Folate Receptor Targeting of Liposomal Doxorubicin In Vitro. Journal of Drug Delivery No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-450712
American Medical Association (AMA)
Kawano, Kumi& Maitani, Yoshie. Effects of Polyethylene Glycol Spacer Length and Ligand Density on Folate Receptor Targeting of Liposomal Doxorubicin In Vitro. Journal of Drug Delivery. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-450712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450712