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Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult
Joint Authors
Lee, Myeong-Jong
Kim, Hojun
Han, Kyung-Wan
Bose, Shambhunath
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Disturbance in the gut microbial niche by antibiotics like neomycin produces gastrointestinal (GI) disorders.
Here, we evaluated the impact of a mixture of extracts of three herbs (Atractylodis Rhizoma Macrocephalae, Massa Medicata Fermentata, and Dolichoris Semen) with known GI protective activities, either laboratory unfermented (herbal formulation-1 (HF-1)) or fermented/re-fermented (herbal formulation-2 (HF-2)) on neomycin-treated rats using a commercial Lactobacillus probiotic as a reference.
Treatment with neomycin augmented stool water content, decreased fecal population of Lactobacillus spp., changed the histology of intestine without inducing inflammation, reduced the colonic expression of zonula occludens-1 (ZO-1) and claudin-1, and elevated the serum C-reactive protein (CRP) and interferon-gamma (IFN-γ) levels.
Coadministration of either HF-2 or probiotic, but not HF-1, restored the fecal content of Lactobacillus spp., normalized the serum CRP level, and significantly increased the colonic expression of ZO-1 and claudin-1 in neomycin-treated rats.
The combined treatment with any of the above agents ameliorated the histological changes of cecum and colon in neomycin-treated rats, and the magnitude of this effect was probiotic > HF-2 > HF-1.
Our study revealed the intestinal protective effect of a mixture of three herbs against neomycin insult, which is mediated through multiple mechanisms and is potentiated upon prior fermentation/refermentation of the herbs.
American Psychological Association (APA)
Bose, Shambhunath& Han, Kyung-Wan& Lee, Myeong-Jong& Kim, Hojun. 2013. Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-450726
Modern Language Association (MLA)
Bose, Shambhunath…[et al.]. Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-450726
American Medical Association (AMA)
Bose, Shambhunath& Han, Kyung-Wan& Lee, Myeong-Jong& Kim, Hojun. Intestinal Protective Effects of Herbal-Based Formulations in Rats against Neomycin Insult. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-450726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450726