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The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders
Joint Authors
Ashwood, Paul
Mulder, Linda
Critchfield, J. William
Ash, Michael
van Hemert, Saskia
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gastrointestinal (GI) dysfunction has been reported in a substantial number of children with autism spectrum disorders (ASD).
Activation of the mucosal immune response and the presence of abnormal gut microbiota are repeatedly observed in these children.
In children with ASD, the presence of GI dysfunction is often associated with increased irritability, tantrums, aggressive behaviour, and sleep disturbances.
Moreover, modulating gut bacteria with short-term antibiotic treatment can lead to temporary improvement in behavioral symptoms in some individuals with ASD.
Probiotics can influence microbiota composition and intestinal barrier function and alter mucosal immune responses.
The administration of probiotic bacteria to address changes in the microbiota might, therefore, be a useful novel therapeutic tool with which to restore normal gut microbiota, reduce inflammation, restore epithelial barrier function, and potentially ameliorate behavioural symptoms associated with some children with ASD.
In this review of the literature, support emerges for the clinical testing of probiotics in ASD, especially in the context of addressing GI symptoms.
American Psychological Association (APA)
Critchfield, J. William& van Hemert, Saskia& Ash, Michael& Mulder, Linda& Ashwood, Paul. 2011. The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-450732
Modern Language Association (MLA)
Critchfield, J. William…[et al.]. The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders. Gastroenterology Research and Practice No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-450732
American Medical Association (AMA)
Critchfield, J. William& van Hemert, Saskia& Ash, Michael& Mulder, Linda& Ashwood, Paul. The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-450732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450732