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Poly(amidoamine) Hydrogels as Scaffolds for Cell Culturing and Conduits for Peripheral Nerve Regeneration
Joint Authors
Ranucci, Elisabetta
Manfredi, Amedea
Fenili, Fabio
Ferruti, Paolo
Source
International Journal of Polymer Science
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-02
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Biodegradable and biocompatible poly(amidoamine)-(PAA-) based hydrogels have been considered for different tissue engineering applications.
First-generation AGMA1 hydrogels, amphoteric but prevailing cationic hydrogels containing carboxylic and guanidine groups as side substituents, show satisfactory results in terms of adhesion and proliferation properties towards different cell lines.
Unfortunately, these hydrogels are very swellable materials, breakable on handling, and have been found inadequate for other applications.
To overcome this problem, second-generation AGMA1 hydrogels have been prepared adopting a new synthetic method.
These new hydrogels exhibit good biological properties in vitro with satisfactory mechanical characteristics.
They are obtained in different forms and shapes and successfully tested in vivo for the regeneration of peripheral nerves.
This paper reports on our recent efforts in the use of first-and second-generation PAA hydrogels as substrates for cell culturing and tubular scaffold for peripheral nerve regeneration.
American Psychological Association (APA)
Fenili, Fabio& Manfredi, Amedea& Ranucci, Elisabetta& Ferruti, Paolo. 2011. Poly(amidoamine) Hydrogels as Scaffolds for Cell Culturing and Conduits for Peripheral Nerve Regeneration. International Journal of Polymer Science،Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-450763
Modern Language Association (MLA)
Fenili, Fabio…[et al.]. Poly(amidoamine) Hydrogels as Scaffolds for Cell Culturing and Conduits for Peripheral Nerve Regeneration. International Journal of Polymer Science No. 2011 (2011), pp.1-20.
https://search.emarefa.net/detail/BIM-450763
American Medical Association (AMA)
Fenili, Fabio& Manfredi, Amedea& Ranucci, Elisabetta& Ferruti, Paolo. Poly(amidoamine) Hydrogels as Scaffolds for Cell Culturing and Conduits for Peripheral Nerve Regeneration. International Journal of Polymer Science. 2011. Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-450763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450763