TCA Cycle Defects and Cancer : When Metabolism Tunes Redox State
Joint Authors
Ciriolo, Maria Rosa
Cardaci, Simone
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years.
Until recently, only recessive mutations were described which, although resulted in severe multisystem syndromes, did not predispose to cancer onset.
In the last ten years, a causal role in carcinogenesis has been documented for inherited and acquired alterations in three TCA cycle enzymes, succinate dehydrogenase (SDH), fumarate hydratase (FH), and isocitrate dehydrogenase (IDH), pointing towards metabolic alterations as the underlying hallmark of cancer.
This paper summarizes the neoplastic alterations of the TCA cycle enzymes focusing on the generation of pseudohypoxic phenotype and the alteration of epigenetic homeostasis as the main tumor-promoting effects of the TCA cycle affecting defects.
Moreover, we debate on the ability of these mutations to affect cellular redox state and to promote carcinogenesis by impacting on redox biology.
American Psychological Association (APA)
Cardaci, Simone& Ciriolo, Maria Rosa. 2012. TCA Cycle Defects and Cancer : When Metabolism Tunes Redox State. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450767
Modern Language Association (MLA)
Cardaci, Simone& Ciriolo, Maria Rosa. TCA Cycle Defects and Cancer : When Metabolism Tunes Redox State. International Journal of Cell Biology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450767
American Medical Association (AMA)
Cardaci, Simone& Ciriolo, Maria Rosa. TCA Cycle Defects and Cancer : When Metabolism Tunes Redox State. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450767