Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer : Rationale and Report of Early Data
Joint Authors
Sugarbaker, Paul H.
Stuart, O. Anthony
Bijelic, Lana
Source
International Journal of Surgical Oncology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Currently, the surgical management of pancreas cancer is recognized around the world as inadequate.
Despite a potentially curative R0 resection, long-term survival is rare.
There is a strong rationale for the use of chemotherapy in the operating room to reduce local-regional of recurrent/progressive disease.
Gemcitabine monotherapy administered by an intraperitoneal route in the operating room with hyperthermia and then for long-term treatment postoperatively has a pharmacologic basis in that the exposure of peritoneal surfaces to intraperitoneal gemcitabine is approximately 200–500 times the exposure that occurs within the plasma.
A standardized treatment with intraoperative and long-term chemotherapy that is well tolerated would greatly facilitate further improvements in pancreas cancer treatment and may lead the way to an evolution of more successful treatment strategies of this dread disease.
The aim of this paper is to present the early data on a protocol in progress in patients with resected pancreatic cancer.
American Psychological Association (APA)
Sugarbaker, Paul H.& Stuart, O. Anthony& Bijelic, Lana. 2011. Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer : Rationale and Report of Early Data. International Journal of Surgical Oncology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-450770
Modern Language Association (MLA)
Sugarbaker, Paul H.…[et al.]. Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer : Rationale and Report of Early Data. International Journal of Surgical Oncology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-450770
American Medical Association (AMA)
Sugarbaker, Paul H.& Stuart, O. Anthony& Bijelic, Lana. Intraperitoneal Gemcitabine Chemotherapy Treatment for Patients with Resected Pancreatic Cancer : Rationale and Report of Early Data. International Journal of Surgical Oncology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-450770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450770