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The Prognostic Value of Lymph Node Cross-Sectional Cancer Area in Node-Positive Breast Cancer : A Comparison with N Stage and Lymph Node Ratio
Joint Authors
Albuquerque, Kevin
Holmes, Earle
Shah, Karan
Li, Yanxia
Erşahin, Çağatay
Szpaderska, Anna
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The number of positive axillary lymph nodes (LNs) is the only node-related factor for prognostic evaluation of breast cancer recognized by AJCC (TNM staging).
However, N staging may not completely reflect LN tumor involvement due to the erroneous count of LNs in the presence of matted LNs and different tumor volume in LNs.
Additionally, the positive/total LN ratio (LNR) has been shown to outperform N staging in survival prediction.
In our study, to better quantify the tumor involvement of axillary LNs, we measured the cross-sectional cancer area (CSCA) of the positive LNs in 292 breast cancer patients diagnosed between 1998 and 2000 in our institution and compared its prognostic value to that of number of positive LNs (metLN)/N stage and LNR.
Statistical analyses of these three LN-related factors were performed by Kaplan-Meier method and multivariate Cox's regression model.
Patients were divided into three groups based on the different LN CSCA (<50, 50–500, and >500 mm2), or LNR (<0.1, 0.1–0.65, and >0.65), or N stage (N1–N3).
Multivariate analysis demonstrated LNR was the most significant LN-related survival predictor with hazard ratio (HR) 25.0 (P=0.001), compared to the metLN (HR 0.09, P=0.052) and CSCA (HR 2.24, P=0.323).
American Psychological Association (APA)
Li, Yanxia& Holmes, Earle& Shah, Karan& Albuquerque, Kevin& Szpaderska, Anna& Erşahin, Çağatay. 2012. The Prognostic Value of Lymph Node Cross-Sectional Cancer Area in Node-Positive Breast Cancer : A Comparison with N Stage and Lymph Node Ratio. Pathology Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450778
Modern Language Association (MLA)
Li, Yanxia…[et al.]. The Prognostic Value of Lymph Node Cross-Sectional Cancer Area in Node-Positive Breast Cancer : A Comparison with N Stage and Lymph Node Ratio. Pathology Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-450778
American Medical Association (AMA)
Li, Yanxia& Holmes, Earle& Shah, Karan& Albuquerque, Kevin& Szpaderska, Anna& Erşahin, Çağatay. The Prognostic Value of Lymph Node Cross-Sectional Cancer Area in Node-Positive Breast Cancer : A Comparison with N Stage and Lymph Node Ratio. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450778