Potential Osteoporosis Recovery by Deep Sea Water through Bone Regeneration in SAMP8 Mice
Joint Authors
Lin, Che-Tong
Liu, Hen-Yu
Chen, Wei-Hong
Shieh, Ying-Hua
Tsai, Ching-Yu
Wang, Ming-Fu
Deng, Win-Ping
Zeng, Rong
Liu, Ming-Che
Wu, Kuan-Hsien
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of this study is to examine the therapeutic potential of deep sea water (DSW) on osteoporosis.
Previously, we have established the ovariectomized senescence-accelerated mice (OVX-SAMP8) and demonstrated strong recovery of osteoporosis by stem cell and platelet-rich plasma (PRP).
Deep sea water at hardness (HD) 1000 showed significant increase in proliferation of osteoblastic cell (MC3T3) by MTT assay.
For in vivo animal study, bone mineral density (BMD) was strongly enhanced followed by the significantly increased trabecular numbers through micro-CT examination after a 4-month deep sea water treatment, and biochemistry analysis showed that serum alkaline phosphatase (ALP) activity was decreased.
For stage-specific osteogenesis, bone marrow-derived stromal cells (BMSCs) were harvested and examined.
Deep sea water-treated BMSCs showed stronger osteogenic differentiation such as BMP2, RUNX2, OPN, and OCN, and enhanced colony forming abilities, compared to the control group.
Interestingly, most untreated OVX-SAMP8 mice died around 10 months; however, approximately 57% of DSW-treated groups lived up to 16.6 months, a life expectancy similar to the previously reported life expectancy for SAMR1 24 months.
The results demonstrated the regenerative potentials of deep sea water on osteogenesis, showing that deep sea water could potentially be applied in osteoporosis therapy as a complementary and alternative medicine (CAM).
American Psychological Association (APA)
Liu, Hen-Yu& Liu, Ming-Che& Wang, Ming-Fu& Chen, Wei-Hong& Tsai, Ching-Yu& Wu, Kuan-Hsien…[et al.]. 2013. Potential Osteoporosis Recovery by Deep Sea Water through Bone Regeneration in SAMP8 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-450779
Modern Language Association (MLA)
Liu, Hen-Yu…[et al.]. Potential Osteoporosis Recovery by Deep Sea Water through Bone Regeneration in SAMP8 Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-450779
American Medical Association (AMA)
Liu, Hen-Yu& Liu, Ming-Che& Wang, Ming-Fu& Chen, Wei-Hong& Tsai, Ching-Yu& Wu, Kuan-Hsien…[et al.]. Potential Osteoporosis Recovery by Deep Sea Water through Bone Regeneration in SAMP8 Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-450779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450779