Molecular Profiling of Endometrial Malignancies
Joint Authors
Yeh, I-Tien
Samarnthai, Norasate
Hall, Kevin
Source
Obstetrics and Gynecology International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-28
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Molecular profiling of endometrial neoplasms reveals genetic changes in endometrial carcinomas that support the dualistic model, in which type I carcinomas are estrogen-dependent, low grade lesions and type II carcinomas are nonestrogen dependent and high grade.
The molecular changes in type I endometrial carcinomas include mutations in PTEN, PIK3CA, KRAS, and β-catenin, along with microsatellite instability, whereas type II endometrial carcinomas are characterized by genetic alterations in p53, HER2/neu, p16, and E-cadherin.
For endometrial neoplasms with a malignant mesenchymal component, C-MYC mutations and loss of heterozygosity are frequently seen in carcinosarcomas, and a fusion gene, JAZF1/JJAZ1, is distinctive for endometrial stromal sarcoma.
In addition, p53 mutations may play an important role in tumorigenesis of undifferentiated endometrial sarcoma.
These molecular changes can help in the diagnosis of endometrial neoplasms, as well as form the basis of molecular targeted therapy.
American Psychological Association (APA)
Samarnthai, Norasate& Hall, Kevin& Yeh, I-Tien. 2010. Molecular Profiling of Endometrial Malignancies. Obstetrics and Gynecology International،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-450805
Modern Language Association (MLA)
Samarnthai, Norasate…[et al.]. Molecular Profiling of Endometrial Malignancies. Obstetrics and Gynecology International No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-450805
American Medical Association (AMA)
Samarnthai, Norasate& Hall, Kevin& Yeh, I-Tien. Molecular Profiling of Endometrial Malignancies. Obstetrics and Gynecology International. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-450805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450805