Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease
Joint Authors
Dong, Xinqian
Lu, Yan
Feng, Yan
Lu, Li
Zhou, Li
Liu, Lifeng
Ren, Xiaoyan
Sang, Weiwei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Aim.
It remains challenging to determine the inflammatory activity in Crohn’s disease (CD) for lack of specific laboratory markers.
Recent studies suggest that serum omentin-1 is associated with inflammatory response.
We aimed to assess the potential of serum omentin-1 as a marker of disease activity in CD patients.
Methods.
Serum omentin-1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA) in patients with CD (n=240), functional gastrointestinal disorders (FGDs, n=120), and healthy controls (HC, n=60) and evaluated for correlation with disease activity.
Expression of omentin-1 in colonic tissues from patients with CD was also analyzed by real-time PCR and Western blotting.
Serum omentin-1 levels as an activity index were evaluated using a receiver operating characteristic (ROC) curve.
Results.
Serum omentin-1 concentrations were significantly decreased in active CD patients compared with patients in remission, FGDs, and HC (all P<0.001).
Expression of omentin-1 was decreased at mRNA and protein levels in inflamed colonic tissues in active CD than that in noninflamed colonic tissues.
Serum omentin-1 levels were negatively correlated with disease activity in CD, better than C-reactive protein (CRP).
Conclusion.
Our results indicate that serum and colonic omentin-1 expressions are decreased in active CD patients.
The correlation of serum omentin-1 with disease activity in CD is superior to that of CRP.
Serum omentin-1 is a potential marker for CD disease activity.
American Psychological Association (APA)
Lu, Yan& Zhou, Li& Liu, Lifeng& Feng, Yan& Lu, Li& Ren, Xiaoyan…[et al.]. 2014. Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease. Disease Markers،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-450829
Modern Language Association (MLA)
Lu, Yan…[et al.]. Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease. Disease Markers No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-450829
American Medical Association (AMA)
Lu, Yan& Zhou, Li& Liu, Lifeng& Feng, Yan& Lu, Li& Ren, Xiaoyan…[et al.]. Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-450829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450829