VEGF Spliced Variants : Possible Role of Anti-Angiogenesis Therapy
Joint Authors
Hilmi, Caroline
Pagès, Gilles
Guyot, Mélanie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Angiogenesis has been targeted in retinopathies, psoriasis, and a variety of cancers (colon, breast, lung, and kidney).
Among these tumour types, clear cell renal cell carcinomas (RCCs) are the most vascularized tumours due to mutations of the von Hippel Lindau gene resulting in HIF-1 alpha stabilisation and overexpression of Vascular Endothelial Growth Factor (VEGF).
Surgical nephrectomy remains the most efficient curative treatment for patients with noninvasive disease, while VEGF targeting has resulted in varying degrees of success for treating metastatic disease.
VEGF pre-mRNA undergoes alternative splicing generating pro-angiogenic isoforms.
However, the recent identification of novel splice variants of VEGF with anti-angiogenic properties has provided some insight for the lack of current treatment efficacy.
Here we discuss an explanation for the relapse to anti-angiogenesis treatment as being due to either an initial or acquired resistance to the therapy.
We also discuss targeting angiogenesis via SR (serine/arginine-rich) proteins implicated in VEGF splicing.
American Psychological Association (APA)
Hilmi, Caroline& Guyot, Mélanie& Pagès, Gilles. 2011. VEGF Spliced Variants : Possible Role of Anti-Angiogenesis Therapy. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-450851
Modern Language Association (MLA)
Hilmi, Caroline…[et al.]. VEGF Spliced Variants : Possible Role of Anti-Angiogenesis Therapy. Journal of Nucleic Acids No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-450851
American Medical Association (AMA)
Hilmi, Caroline& Guyot, Mélanie& Pagès, Gilles. VEGF Spliced Variants : Possible Role of Anti-Angiogenesis Therapy. Journal of Nucleic Acids. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-450851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450851