Association between Severe Upper Limb Spasticity and Brain Lesion Location in Stroke Patients
Joint Authors
Smania, Nicola
Tamburin, Stefano
Praitano, Marialuigia
Saltuari, Leopold
Picelli, Alessandro
Gajofatto, Francesca
Corradini, Claudio
Zanette, Giampietro
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Association between the site of brain injury and poststroke spasticity is poorly understood.
The present study investigated whether lesion analysis could document brain regions associated with the development of severe upper limb poststroke spasticity.
A retrospective analysis was conducted on 39 chronic stroke patients.
Spasticity was assessed at the affected upper limb with the modified Ashworth scale (shoulder, elbow, wrist, and fingers).
Brain lesions were traced from magnetic resonance imaging performed within the first 7 days after stroke and region of interest images were generated.
The association between severe upper limb spasticity (modified Ashworth scale ≥2) and lesion location was determined with the voxel-based lesion-symptom mapping method implemented in MRIcro software.
Colored maps representing the z statistics were generated and overlaid onto the automated anatomical labeling and the Johns Hopkins University white matter templates provided with MRIcron.
Thalamic nuclei were identified with the Talairach Daemon software.
Injuries to the insula, the thalamus, the basal ganglia, and white matter tracts (internal capsule, corona radiata, external capsule, and superior longitudinal fasciculus) were significantly associated with severe upper limb poststroke spasticity.
Further advances in our understanding of the neural correlates of spasticity may lead to early targeted rehabilitation when key regions are damaged.
American Psychological Association (APA)
Picelli, Alessandro& Tamburin, Stefano& Gajofatto, Francesca& Zanette, Giampietro& Praitano, Marialuigia& Saltuari, Leopold…[et al.]. 2014. Association between Severe Upper Limb Spasticity and Brain Lesion Location in Stroke Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-450855
Modern Language Association (MLA)
Picelli, Alessandro…[et al.]. Association between Severe Upper Limb Spasticity and Brain Lesion Location in Stroke Patients. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-450855
American Medical Association (AMA)
Picelli, Alessandro& Tamburin, Stefano& Gajofatto, Francesca& Zanette, Giampietro& Praitano, Marialuigia& Saltuari, Leopold…[et al.]. Association between Severe Upper Limb Spasticity and Brain Lesion Location in Stroke Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-450855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450855