![](/images/graphics-bg.png)
Translocator Protein (18 kDa) : A Promising Therapeutic Target and Diagnostic Tool for Cardiovascular Diseases
Joint Authors
Xiao, Junjie
Wang, Fei
Xu, Jiahong
Qi, Xiaolong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The translocator protein (18 kDa) (TSPO) is a five transmembrane domain protein in mitochondria, abundantly expressed in a variety of organs and tissues.
TSPO contributes to a wide range of biological processes, including cholesterol transportation, mitochondrial membrane potential and respiratory chain regulation, apoptosis, and oxidative stress.
Recent studies have demonstrated that TSPO might also be involved in the physiological regulation of cardiac chronotropy and inotropy.
Accordingly, TSPO ligands play significant roles in protecting the cardiovascular systems under pathological conditions through cardiac electrical activity retention, intracellular calcium maintenance, mitochondrial energy provision, mitochondrial membrane potential equilibrium, and reactive oxygen species inhibition.
This paper focuses on the physiological and pathological characteristics of TSPO in the cardiovascular systems and also summarizes the properties of TSPO ligands.
TSPO represents a potential therapeutic target and diagnostic tool for cardiovascular diseases including arrhythmia, myocardial infarction, cardiac hypertrophy, atherosclerosis, myocarditis, and large vessel vasculitis.
American Psychological Association (APA)
Qi, Xiaolong& Xu, Jiahong& Wang, Fei& Xiao, Junjie. 2012. Translocator Protein (18 kDa) : A Promising Therapeutic Target and Diagnostic Tool for Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450873
Modern Language Association (MLA)
Qi, Xiaolong…[et al.]. Translocator Protein (18 kDa) : A Promising Therapeutic Target and Diagnostic Tool for Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450873
American Medical Association (AMA)
Qi, Xiaolong& Xu, Jiahong& Wang, Fei& Xiao, Junjie. Translocator Protein (18 kDa) : A Promising Therapeutic Target and Diagnostic Tool for Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450873