![](/images/graphics-bg.png)
Rate Control in Atrial Fibrillation by Cooling : Effect of Temperature on Dromotropy in Perfused Rabbit Hearts
Joint Authors
Knackstedt, Christian
Zarse, Markus
Mischke, Karl
Schauerte, Patrick
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-13
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Cooling has emerged as a therapeutic option in critically ill patients (especially after cardiac resuscitation) and might also have a negative dromotropic effect in atrial fibrillation.
We sought to determine the impact of cooling on electrophysiologic properties of Langendorff-perfused rabbit hearts.
Methods and Results.
In 20 isolated Langendorff-perfused rabbit hearts, the temperature of the tissue bath was changed between 17 and 42°C.
With decreasing temperature, significant increases of the spontaneous sinus cycle length, decreases of the mean ventricular heart rate during atrial fibrillation, and relevant increases of atrial and ventricular refractory periods were observed (ANOVA P<.01).
Conclusions.
Cardiac hypothermia leads to a significant drop of mean ventricular heart rate during atrial fibrillation.
Negative chronotropy and dromotropy induced by moderate cardiac hypothermia might be a feasible therapeutic approach in patients with hemodynamically relevant tachyarrhythmias in a CCU/ICU setting.
American Psychological Association (APA)
Mischke, Karl& Zarse, Markus& Knackstedt, Christian& Schauerte, Patrick. 2011. Rate Control in Atrial Fibrillation by Cooling : Effect of Temperature on Dromotropy in Perfused Rabbit Hearts. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-450881
Modern Language Association (MLA)
Mischke, Karl…[et al.]. Rate Control in Atrial Fibrillation by Cooling : Effect of Temperature on Dromotropy in Perfused Rabbit Hearts. Cardiology Research and Practice No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-450881
American Medical Association (AMA)
Mischke, Karl& Zarse, Markus& Knackstedt, Christian& Schauerte, Patrick. Rate Control in Atrial Fibrillation by Cooling : Effect of Temperature on Dromotropy in Perfused Rabbit Hearts. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-450881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450881