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International Heart Valve Bank Survey : A Review of Processing Practices and Activity Outcomes
Joint Authors
Heng, Wee Ling
Lim, Yeong Phang
Manning, Linda
Chiappini, Paul
Albrecht, Helmi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A survey of 24 international heart valve banks was conducted to acquire information on heart valve processing techniques used and outcomes achieved.
The objective was to provide an overview of heart valve banking activities for tissue bankers, tissue banking associations, and regulatory bodies worldwide.
Despite similarities found for basic manufacturing processes, distinct differences in procedural details were also identified.
The similarities included (1) use of sterile culture media for procedures, (2) antibiotic decontamination, (3) use of dimethyl sulfoxide (DMSO) as a cryoprotectant, (4) controlled rate freezing for cryopreservation, and (5) storage at ultralow temperatures of below −135°C.
Differences in procedures included (1) type of sterile media used, (2) antibiotics combination, (3) temperature and duration used for bioburden reduction, (4) concentration of DMSO used for cryopreservation, and (5) storage duration for released allografts.
For most banks, the primary reasons why allografts failed to meet release criteria were positive microbiological culture and abnormal morphology.
On average, 85% of allografts meeting release criteria were implanted, with valve size and type being the main reasons why released allografts were not used clinically.
The wide variation in percentage of allografts meeting release requirements, despite undergoing validated manufacturing procedures, justifies the need for regular review of important outcomes as cited in this paper, in order to encourage comparison and improvements in the HVBs’ processes.
American Psychological Association (APA)
Heng, Wee Ling& Albrecht, Helmi& Chiappini, Paul& Lim, Yeong Phang& Manning, Linda. 2013. International Heart Valve Bank Survey : A Review of Processing Practices and Activity Outcomes. Journal of Transplantation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-450896
Modern Language Association (MLA)
Heng, Wee Ling…[et al.]. International Heart Valve Bank Survey : A Review of Processing Practices and Activity Outcomes. Journal of Transplantation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-450896
American Medical Association (AMA)
Heng, Wee Ling& Albrecht, Helmi& Chiappini, Paul& Lim, Yeong Phang& Manning, Linda. International Heart Valve Bank Survey : A Review of Processing Practices and Activity Outcomes. Journal of Transplantation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-450896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450896