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Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana
Joint Authors
Sülsen, Valeria P.
Tonn, Carlos
Martino, Virginia S.
Barrera, Patricia
Lozano, Esteban
Beer, María Florencia
Rivera, Mónica
Sosa, Miguel A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Leishmaniasis is a worldwide parasitic disease, caused by monoflagellate parasites of the genus Leishmania.
In the search for more effective agents against these parasites, the identification of molecular targets has been attempted to ensure the efficiency of drugs and to avoid collateral damages on the host’s cells.
In this work, we have investigated some of the mechanisms of action of a group of natural sesquiterpene lactones that are effective against Leishmania mexicana mexicana promastigotes.
We first observed that the antiproliferative effect of mexicanin I (Mxc), dehydroleucodine (DhL), psilostachyin (Psi), and, at lesser extent, psilostachyin C (Psi C) is blocked by 1.5 mM reduced glutathione.
The reducing agent was also able to reverse the early effect of the compounds, suggesting that lactones may react with intracellular sulfhydryl groups.
Moreover, we have shown that all the sesquiterpene lactones, except Psi C, significantly decreased the endogenous concentration of glutathione within the parasite.
Consistent with these findings, the active sesquiterpene lactones increased between 2.7 and 5.4 times the generation of ROS by parasites.
These results indicate that the induction of oxidative stress is at least one of the mechanisms of action of DhL, Mxc, and Psi on parasites while Psi C would act by another mechanism.
American Psychological Association (APA)
Barrera, Patricia& Sülsen, Valeria P.& Lozano, Esteban& Rivera, Mónica& Beer, María Florencia& Tonn, Carlos…[et al.]. 2013. Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450912
Modern Language Association (MLA)
Barrera, Patricia…[et al.]. Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-450912
American Medical Association (AMA)
Barrera, Patricia& Sülsen, Valeria P.& Lozano, Esteban& Rivera, Mónica& Beer, María Florencia& Tonn, Carlos…[et al.]. Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450912