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Detection of Melanoma Metastases in Resected Human Lymph Nodes by Noninvasive Multispectral Photoacoustic Imaging
Joint Authors
Langhout, Gerrit Cornelis
Jose, Jithin
Grootendorst, Diederik Johannes
Wouters, Michel Wilhelmus Jacobus Maria
van Boven, Hester
Nieweg, Omgo Edo
Ruers, Theodoor Jacques Marie
van der Hage, Jos Alexander
Steenbergen, Wiendelt
Manohar, Srirang
Source
International Journal of Biomedical Imaging
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Sentinel node biopsy in patients with cutaneous melanoma improves staging, provides prognostic information, and leads to an increased survival in node-positive patients.
However, frozen section analysis of the sentinel node is not reliable and definitive histopathology evaluation requires days, preventing intraoperative decision-making and immediate therapy.
Photoacoustic imaging can evaluate intact lymph nodes, but specificity can be hampered by other absorbers such as hemoglobin.
Near infrared multispectral photoacoustic imaging is a new approach that has the potential to selectively detect melanin.
The purpose of the present study is to examine the potential of multispectral photoacoustic imaging to identify melanoma metastasis in human lymph nodes.
Methods.
Three metastatic and nine benign lymph nodes from eight melanoma patients were scanned ex vivo using a Vevo LAZR© multispectral photoacoustic imager and were spectrally analyzed per pixel.
The results were compared to histopathology as gold standard.
Results.
The nodal volume could be scanned within 20 minutes.
An unmixing procedure was proposed to identify melanoma metastases with multispectral photoacoustic imaging.
Ultrasound overlay enabled anatomical correlation.
The penetration depth of the photoacoustic signal was up to 2 cm.
Conclusion.
Multispectral three-dimensional photoacoustic imaging allowed for selective identification of melanoma metastases in human lymph nodes.
American Psychological Association (APA)
Langhout, Gerrit Cornelis& Grootendorst, Diederik Johannes& Nieweg, Omgo Edo& Wouters, Michel Wilhelmus Jacobus Maria& van der Hage, Jos Alexander& Jose, Jithin…[et al.]. 2014. Detection of Melanoma Metastases in Resected Human Lymph Nodes by Noninvasive Multispectral Photoacoustic Imaging. International Journal of Biomedical Imaging،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-450935
Modern Language Association (MLA)
Langhout, Gerrit Cornelis…[et al.]. Detection of Melanoma Metastases in Resected Human Lymph Nodes by Noninvasive Multispectral Photoacoustic Imaging. International Journal of Biomedical Imaging No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-450935
American Medical Association (AMA)
Langhout, Gerrit Cornelis& Grootendorst, Diederik Johannes& Nieweg, Omgo Edo& Wouters, Michel Wilhelmus Jacobus Maria& van der Hage, Jos Alexander& Jose, Jithin…[et al.]. Detection of Melanoma Metastases in Resected Human Lymph Nodes by Noninvasive Multispectral Photoacoustic Imaging. International Journal of Biomedical Imaging. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-450935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450935