Biologic Therapy in Head and Neck Cancer : A Road with Hurdles
Joint Authors
Specenier, Pol
Vermorken, Jan Baptist
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The epidermal growth factor receptor (EGFR) is overexpressed in the vast majority of cases of squamous cell carcinoma of the head and neck (SCCHN).
A high EGFR expression is associated with an unfavorable prognosis.
Cetuximab is a chimeric human/murine IgG1 antibody which binds with high affinity to the EGFR.
It is the only targeted agent which got approval for the treatment of SCCHN from the regulatory agencies of Europe and the United States, both in locoregionally advanced disease, in association with radiation, and in recurrent/metastatic disease.
The outcome of trials involving other EGFR-directed monoclonal antibodies, that is, zalutumumab and panitumumab, was consistent with the results with cetuximab.
However these trials failed to meet their primary endpoint.
The results with EGFR-directed tyrosine kinase inhibitors have been disappointing.
Other potential targets for treatment in SCCHN include the entire ErbB family, the vascular endothelial growth factor (VEGF) and its receptor (VEGFR), the insulin-like growth factor 1 receptor (IGF-1R), the insulin receptor (IR), histone deacetylases (HDAC), the mammalian target of rapamycin (mTOR), the platelet-derived growth factor receptor (PDGFR), heat-shock protein 90 (HSP90), nuclear factor-kappa B (NF-κB), aurora A or B, and phosphatidylinositol 3-kinase (PIK3CA).
American Psychological Association (APA)
Specenier, Pol& Vermorken, Jan Baptist. 2012. Biologic Therapy in Head and Neck Cancer : A Road with Hurdles. ISRN Oncology،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-450945
Modern Language Association (MLA)
Specenier, Pol& Vermorken, Jan Baptist. Biologic Therapy in Head and Neck Cancer : A Road with Hurdles. ISRN Oncology No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-450945
American Medical Association (AMA)
Specenier, Pol& Vermorken, Jan Baptist. Biologic Therapy in Head and Neck Cancer : A Road with Hurdles. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-450945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450945