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The Role of Protein Arginine Methylation in mRNP Dynamics
Author
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In eukaryotes, messenger RNA biogenesis depends on the ordered and precise assembly of a nuclear messenger ribonucleoprotein particle (mRNP) during transcription.
This process requires a well-orchestrated and dynamic sequence of molecular recognition events by specific RNA-binding proteins.
Arginine methylation is a posttranslational modification found in a plethora of RNA-binding proteins responsible for mRNP biogenesis.
These RNA-binding proteins include both heterogeneous nuclear ribonucleoproteins (hnRNPs) and serine/arginine-rich (SR) proteins.
In this paper, I discuss the mechanisms of action by which arginine methylation modulates various facets of mRNP biogenesis, and how the collective consequences of this modification impart the specificity required to generate a mature, translational- and export-competent mRNP.
American Psychological Association (APA)
Yu, Michael C.. 2011. The Role of Protein Arginine Methylation in mRNP Dynamics. Molecular Biology International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-450952
Modern Language Association (MLA)
Yu, Michael C.. The Role of Protein Arginine Methylation in mRNP Dynamics. Molecular Biology International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-450952
American Medical Association (AMA)
Yu, Michael C.. The Role of Protein Arginine Methylation in mRNP Dynamics. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-450952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450952