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The Bad, the Good, and the Ugly about Oxidative Stress
Joint Authors
Velez-Pardo, Carlos
Jimenez-Del-Rio, Marlene
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Alzheimer’s disease (AD), Parkinson’s disease (PD), and cancer (e.g., leukemia) are the most devastating disorders affecting millions of people worldwide.
Except for some kind of cancers, no effective and/or definitive therapeutic treatment aimed to reduce or to retard the clinic and pathologic symptoms induced by AD and PD is presently available.
Therefore, it is urgently needed to understand the molecular basis of these disorders.
Since oxidative stress (OS) is an important etiologic factor of the pathologic process of AD, PD, and cancer, understanding how intracellular signaling pathways respond to OS will have a significant implication in the therapy of these diseases.
Here, we propose a model of minimal completeness of cell death signaling induced by OS as a mechanistic explanation of neuronal and cancer cell demise.
This mechanism might provide the basis for therapeutic design strategies.
Finally, we will attempt to associate PD, cancer, and OS.
This paper critically analyzes the evidence that support the “oxidative stress model” in neurodegeneration and cancer.
American Psychological Association (APA)
Jimenez-Del-Rio, Marlene& Velez-Pardo, Carlos. 2012. The Bad, the Good, and the Ugly about Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-450963
Modern Language Association (MLA)
Jimenez-Del-Rio, Marlene& Velez-Pardo, Carlos. The Bad, the Good, and the Ugly about Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-450963
American Medical Association (AMA)
Jimenez-Del-Rio, Marlene& Velez-Pardo, Carlos. The Bad, the Good, and the Ugly about Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-450963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450963