Clinical Responses to Rituximab in a Case of Neuroblastoma with Refractory Opsoclonus Myoclonus Ataxia Syndrome
Joint Authors
Alavi, Samin
Arzanian, Mohammad Taghi
Moradveisi, Borhan
Aminasnafi, Ali
Kord Valeshabad, Ali
Source
Case Reports in Oncological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Opsoclonus myoclonus ataxia syndrome (OMS) is a rare neurologic syndrome.
In a high proportion of children, it is associated with neuroblastoma.
The etiology of this condition is thought to be immune mediated.
In children, immunotherapy with conventional treatments such as corticosteroids, intravenous immunoglobulin, adrenocorticotropic hormone, and even antiepileptic drugs has been tried.
Recently rituximab has been used safely for refractory OMS in children with neuroblastoma.
Our patient was a 3.5-year-old girl referred for ataxia and dancing eye movements starting since 1.5 years ago.
She was diagnosed with neuroblastoma on imaging studies on admission.
The OMS was refractory to surgical resection, chemotherapy, corticosteroids, and intravenous immunoglobulin.
Patient received rituximab simultaneously with chemotherapy.
The total severity score decreased by 61.1% after rituximab.
Patient's ataxia markedly improved that she was able to walk independently after 6 months.
Our case confirmed the clinical efficacy and safety of rituximab in a refractory case of OMS.
American Psychological Association (APA)
Alavi, Samin& Kord Valeshabad, Ali& Moradveisi, Borhan& Aminasnafi, Ali& Arzanian, Mohammad Taghi. 2012. Clinical Responses to Rituximab in a Case of Neuroblastoma with Refractory Opsoclonus Myoclonus Ataxia Syndrome. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-450980
Modern Language Association (MLA)
Alavi, Samin…[et al.]. Clinical Responses to Rituximab in a Case of Neuroblastoma with Refractory Opsoclonus Myoclonus Ataxia Syndrome. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-450980
American Medical Association (AMA)
Alavi, Samin& Kord Valeshabad, Ali& Moradveisi, Borhan& Aminasnafi, Ali& Arzanian, Mohammad Taghi. Clinical Responses to Rituximab in a Case of Neuroblastoma with Refractory Opsoclonus Myoclonus Ataxia Syndrome. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-450980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450980