PPAR-δ in Vascular Pathophysiology

Abstract EN

Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-α, β/δ, and γ.

PPAR-δ, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair.

Emerging evidence has also demonstrated that PPAR-δ is implicated in lipids and glucose metabolism.

Most recently, the direct effects of PPAR-δ on cardiovascular processes such as endothelial function and angiogenesis have also been investigated.

Therefore, it is suggested that PPAR-δ may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.