Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice
Joint Authors
de Freitas Alves, Claudiney
Lemos de Andrade, Ednéia
Lazo Chica, Javier Emilio
Artério Sorgi, Carlos
Faccioli, Lúcia Helena
Favarin, Daniely Cornélio
Martins Teixeira, Maxelle
de Paula Rogerio, Alexandre
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, and no specific therapy is still available.
Ellagic acid, a compound present in several fruits and medicinal plants, has shown anti-inflammatory activity in several experimental disease models.
We used the nonlethal acid aspiration model of ALI in mice to determine whether preventive or therapeutic administration of ellagic acid (10 mg/kg; oral route) could interfere with the development or establishment of ALI inflammation.
Dexamethasone (1 mg/kg; subcutaneous route) was used as a positive control.
In both preventive and therapeutic treatments, ellagic acid reduced the vascular permeability changes and neutrophil recruitment to the bronchoalveolar lavage fluid (BALF) and to lung compared to the vehicle.
In addition, the ellagic acid accelerated the resolution for lung neutrophilia.
Moreover, ellagic acid reduced the COX-2-induced exacerbation of inflammation.
These results were similar to the dexamethasone.
However, while the anti-inflammatory effects of dexamethasone treatment were due to the reduced activation of NF-κB and AP-1, the ellagic acid treatment led to reduced BALF levels of IL-6 and increased levels of IL-10.
In addition, dexamethasone treatment reduced IL-1β.
Together, these findings identify ellagic acid as a potential therapeutic agent for ALI-associated inflammation.
American Psychological Association (APA)
Favarin, Daniely Cornélio& Martins Teixeira, Maxelle& Lemos de Andrade, Ednéia& de Freitas Alves, Claudiney& Lazo Chica, Javier Emilio& Artério Sorgi, Carlos…[et al.]. 2013. Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-450992
Modern Language Association (MLA)
Favarin, Daniely Cornélio…[et al.]. Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-450992
American Medical Association (AMA)
Favarin, Daniely Cornélio& Martins Teixeira, Maxelle& Lemos de Andrade, Ednéia& de Freitas Alves, Claudiney& Lazo Chica, Javier Emilio& Artério Sorgi, Carlos…[et al.]. Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-450992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450992