Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma
Joint Authors
Smith, Jeffrey B.
Detels, Roger
Popoviciu, Laura M.
Breen, Elizabeth C.
Gui, Dorina
Said, Jonathan W.
Kitchen, Christina Ramirez
Widney, Daniel P.
Huang, Xin
Martínez-Maza, Otoniel
Alcantar, Juan M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5.
CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors.
Objective.
To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL).
Methods.
Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls.
The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines.
Results.
Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls.
All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression.
AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13.
Conclusions.
CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology.
CXCL13 may have potential as a biomarker for AIDS-NHL.
American Psychological Association (APA)
Widney, Daniel P.& Gui, Dorina& Popoviciu, Laura M.& Said, Jonathan W.& Breen, Elizabeth C.& Huang, Xin…[et al.]. 2010. Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma. AIDS Research and Treatment،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-451026
Modern Language Association (MLA)
Widney, Daniel P.…[et al.]. Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma. AIDS Research and Treatment No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-451026
American Medical Association (AMA)
Widney, Daniel P.& Gui, Dorina& Popoviciu, Laura M.& Said, Jonathan W.& Breen, Elizabeth C.& Huang, Xin…[et al.]. Expression and Function of the Chemokine, CXCL13, and Its Receptor, CXCR5, in Aids-Associated Non-Hodgkin's Lymphoma. AIDS Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-451026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451026
