Mechanisms of Oxidative Damage in Multiple Sclerosis and a Cell Therapy Approach to Treatment
Joint Authors
Wilkins, Alastair
Kemp, Kevin
Scolding, Neil
Witherick, Jonathan
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although significant advances have recently been made in the understanding and treatment of multiple sclerosis, reduction of long-term disability remains a key goal.
Evidence suggests that inflammation and oxidative stress within the central nervous system are major causes of ongoing tissue damage in the disease.
Invading inflammatory cells, as well as resident central nervous system cells, release a number of reactive oxygen and nitrogen species which cause demyelination and axonal destruction, the pathological hallmarks of multiple sclerosis.
Reduction in oxidative damage is an important therapeutic strategy to slow or halt disease processes.
Many drugs in clinical practice or currently in trial target this mechanism.
Cell-based therapies offer an alternative source of antioxidant capability.
Classically thought of as being important for myelin or cell replacement in multiple sclerosis, stem cells may, however, have a more important role as providers of supporting factors or direct attenuators of the disease.
In this paper we focus on the antioxidant properties of mesenchymal stem cells and discuss their potential importance as a cell-based therapy for multiple sclerosis.
American Psychological Association (APA)
Witherick, Jonathan& Wilkins, Alastair& Scolding, Neil& Kemp, Kevin. 2010. Mechanisms of Oxidative Damage in Multiple Sclerosis and a Cell Therapy Approach to Treatment. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-451028
Modern Language Association (MLA)
Witherick, Jonathan…[et al.]. Mechanisms of Oxidative Damage in Multiple Sclerosis and a Cell Therapy Approach to Treatment. Autoimmune Diseases No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-451028
American Medical Association (AMA)
Witherick, Jonathan& Wilkins, Alastair& Scolding, Neil& Kemp, Kevin. Mechanisms of Oxidative Damage in Multiple Sclerosis and a Cell Therapy Approach to Treatment. Autoimmune Diseases. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-451028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451028