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Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats
Joint Authors
Li, Xiao-Tao
Sun, Lei
Shen, Lei
Wang, Peng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In the present study, we investigated the anti-inflammatory activity of water-soluble polysaccharide of Agaricus blazei Murill (WSP-AbM) on ovariectomized osteopenic rats.
The rats were administered orally WSP-AbM (200 mg/kg BW) for 8 weeks.
Subsequent serum maleic dialdehyde (MDA) level, total antioxidant status (TAOS), nuclear factor kappa B (NF-κB) level, polymorphonuclear (PMN) cells level, interleukin-1β (IL-1β) level, inducible nitric oxide synthase (iNOS) level, tumor necrosis factor-α (TNF-α) level, adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry, respectively.
WSP-AbM administration markedly (P<0.05) decreased serum IL-1β and TNF-α levels and the expressions of ICAM-1, COX-2, and iNOS NF-κB compared with OVX rats.
WSP-AbM administration alsomarkedly (P<0.05) decreased PMN infiltration.
In conclusion, we observed that WSP-AbM supplementation had anti-inflammatory effects in a model of osteoporosis disease.
American Psychological Association (APA)
Wang, Peng& Li, Xiao-Tao& Sun, Lei& Shen, Lei. 2013. Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-451046
Modern Language Association (MLA)
Wang, Peng…[et al.]. Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-451046
American Medical Association (AMA)
Wang, Peng& Li, Xiao-Tao& Sun, Lei& Shen, Lei. Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-451046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451046