Cells in Dengue Virus Infection In Vivo
Joint Authors
Hsiao, Hui-Mien
Noisakran, Sansanee
Perng, Guey Chuen
Onlamoon, Nattawat
Chokephaibulkit, Kulkanya
Songprakhon, Pucharee
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Dengue has been recognized as one of the most important vector-borne emerging infectious diseases globally.
Though dengue normally causes a self-limiting infection, some patients may develop a life-threatening illness, dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS).
The reason why DHF/DSS occurs in certain individuals is unclear.
Studies in the endemic regions suggest that the preexisting antibodies are a risk factor for DHF/DSS.
Viremia and thrombocytopenia are the key clinical features of dengue virus infection in patients.
The amounts of virus circulating in patients are highly correlated with severe dengue disease, DHF/DSS.
Also, the disturbance, mainly a transient depression, of hematological cells is a critical clinical finding in acute dengue patients.
However, the cells responsible for the dengue viremia are unresolved in spite of the intensive efforts been made.
Dengue virus appears to replicate and proliferate in many adapted cell lines, but these in vitro properties are extremely difficult to be reproduced in primary cells or in vivo.
This paper summarizes reports on the permissive cells in vitro and in vivo and suggests a hematological cell lineage for dengue virus infection in vivo, with the hope that a new focus will shed light on further understanding of the complexities of dengue disease.
American Psychological Association (APA)
Noisakran, Sansanee& Onlamoon, Nattawat& Songprakhon, Pucharee& Hsiao, Hui-Mien& Chokephaibulkit, Kulkanya& Perng, Guey Chuen. 2010. Cells in Dengue Virus Infection In Vivo. Advances in Virology،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-451056
Modern Language Association (MLA)
Noisakran, Sansanee…[et al.]. Cells in Dengue Virus Infection In Vivo. Advances in Virology No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-451056
American Medical Association (AMA)
Noisakran, Sansanee& Onlamoon, Nattawat& Songprakhon, Pucharee& Hsiao, Hui-Mien& Chokephaibulkit, Kulkanya& Perng, Guey Chuen. Cells in Dengue Virus Infection In Vivo. Advances in Virology. 2010. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-451056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451056