Diagnosis of B-Cell Non-Hodgkin Lymphomas with Small-Intermediate-Sized Cells in Cytopathology
Joint Authors
Geddie, William R.
Schwock, Joerg
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Fine needle sampling is a fast, safe, and potentially cost-effective method of obtaining tissue for cytomorphologic assessment aimed at both initial triage and, in some cases, complete diagnosis of patients that present clinically with lymphadenopathy.
The cytologic diagnosis of B-cell non-Hodgkin lymphomas composed of small-/intermediate-sized cells, however, has been seen as an area of great difficulty even for experienced observers due to the morphologic overlap between lymphoma and reactive lymphadenopathies as well as between the lymphoma entities themselves.
Although ancillary testing has improved diagnostic accuracy, the results from these tests must be interpreted within the morphological and clinical context to avoid misinterpretation.
Importantly, the recognition of specific cytologic features is crucial in guiding the appropriate selection of ancillary tests which will either confirm or refute a tentative diagnosis.
For these reasons, we here review the cytologic characteristics particular to five common B-cell non-Hodgkin lymphomas which typically cause the most diagnostic confusion based on cytological assessment alone: marginal zone lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and lymphoplasmacytic lymphoma.
We summarize the most pertinent cytomorphologic features for each entity as well as for reactive lymphoid hyperplasia, contrast them with each other to facilitate their recognition, and highlight common diagnostic pitfalls.
American Psychological Association (APA)
Schwock, Joerg& Geddie, William R.. 2012. Diagnosis of B-Cell Non-Hodgkin Lymphomas with Small-Intermediate-Sized Cells in Cytopathology. Pathology Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-451063
Modern Language Association (MLA)
Schwock, Joerg& Geddie, William R.. Diagnosis of B-Cell Non-Hodgkin Lymphomas with Small-Intermediate-Sized Cells in Cytopathology. Pathology Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-451063
American Medical Association (AMA)
Schwock, Joerg& Geddie, William R.. Diagnosis of B-Cell Non-Hodgkin Lymphomas with Small-Intermediate-Sized Cells in Cytopathology. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-451063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451063