Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and Pathology

Joint Authors

Deth, Richard C.
Ralston, Nicholas V. C.
Raymond, Laura J.

Source

Autism Research and Treatment

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-03-05

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Diseases

Abstract EN

Autism and autism spectrum disorders (ASDs) are behaviorally defined, but the biochemical pathogenesis of the underlying disease process remains uncharacterized.

Studies indicate that antioxidant status is diminished in autistic subjects, suggesting its pathology is associated with augmented production of oxidative species and/or compromised antioxidant metabolism.

This suggests ASD may result from defects in the metabolism of cellular antioxidants which maintain intracellular redox status by quenching reactive oxygen species (ROS).

Selenium-dependent enzymes (selenoenzymes) are important in maintaining intercellular reducing conditions, particularly in the brain.

Selenoenzymes are a family of ~25 genetically unique proteins, several of which have roles in preventing and reversing oxidative damage in brain and endocrine tissues.

Since the brain’s high rate of oxygen consumption is accompanied by high ROS production, selenoenzyme activities are particularly important in this tissue.

Because selenoenzymes can be irreversibly inhibited by many electrophiles, exposure to these organic and inorganic agents can diminish selenoenzyme-dependent antioxidant functions.

This can impair brain development, particularly via the adverse influence of oxidative stress on epigenetic regulation.

Here we review the physiological roles of selenoproteins in relation to potential biochemical mechanisms of ASD etiology and pathology.

American Psychological Association (APA)

Raymond, Laura J.& Deth, Richard C.& Ralston, Nicholas V. C.. 2014. Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and Pathology. Autism Research and Treatment،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-451065

Modern Language Association (MLA)

Raymond, Laura J.…[et al.]. Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and Pathology. Autism Research and Treatment No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-451065

American Medical Association (AMA)

Raymond, Laura J.& Deth, Richard C.& Ralston, Nicholas V. C.. Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and Pathology. Autism Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-451065

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-451065