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Vitamin D Status in Patients Operated for Primary Hyperparathyroidism : Comparison of Patients from Southern and Northern Europe
Joint Authors
Sancho, Joan J.
Thier, Mark
Almquist, Martin
Nordenström, Erik
Sitges-Serra, Antonio
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood.
The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery.
Methods.
We compared two cohorts of postmenopausal women from Spain (n=126) and Sweden (n=128) that had first-time surgery for sporadic, uniglandular PHPT.
Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3 (25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively.
Results.
Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium levels were higher in the Spanish cohort.
The Spanish patients had higher preoperative levels of PTH (13.5 versus 11.0 pmol/L, P<0.001), urinary calcium (7.3 versus 4.1 mmol/L, P<0.001), and heavier adenomas (620 versus 500 g, P<0.001).
The mean increase in BMD was higher in patients from Spain and in patients with vitamin D deficiency one year after surgery.
Conclusion.
Postmenopasual women with PHPT from Spain had a more advanced disease and lower vitamin 25(OH)D levels.
Improvement in bone density one year after surgery was higher in patients with preoperative vitamin D deficiency.
American Psychological Association (APA)
Nordenström, Erik& Sitges-Serra, Antonio& Sancho, Joan J.& Thier, Mark& Almquist, Martin. 2013. Vitamin D Status in Patients Operated for Primary Hyperparathyroidism : Comparison of Patients from Southern and Northern Europe. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-451066
Modern Language Association (MLA)
Nordenström, Erik…[et al.]. Vitamin D Status in Patients Operated for Primary Hyperparathyroidism : Comparison of Patients from Southern and Northern Europe. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-451066
American Medical Association (AMA)
Nordenström, Erik& Sitges-Serra, Antonio& Sancho, Joan J.& Thier, Mark& Almquist, Martin. Vitamin D Status in Patients Operated for Primary Hyperparathyroidism : Comparison of Patients from Southern and Northern Europe. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-451066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451066