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Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease : An Immunohistochemical Investigation
Joint Authors
Kambayashi, Yumi
Furudate, Sadanori
Aiba, Setsuya
Fujimura, Taku
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Invasive extramammary Paget’s disease (EMPD) is relatively rare and is reported to be highly metastatic to lymph nodes or even other organs, including bone.
Histologically, EMPD shows significant numbers of lymphocytes around the tumor mass, suggesting the possible development of novel immunomodulatory therapy for EMPD by targeting these infiltrating lymphocytes.
Previously, bisphosphonates (BPs) were administered for the treatment of malignancy, especially osteolytic bone disease.
Recent reports also suggested that BPs might have a direct antitumor effect through several pathways beyond their beneficial effect on bone metastasis.
Among them, the abrogation of immunosuppressive cells, myeloid derived suppressor cells (MDSC), by BPs might be one of the optimal methods to induce an antitumor immune response both locally and at sites remote from the tumor.
In this study, we employed immunohistochemical staining for immunosuppressive macrophages and cytotoxic T cells in the lesional skin of patients with noninvasive EMPD and those with invasive EMPD.
American Psychological Association (APA)
Fujimura, Taku& Furudate, Sadanori& Kambayashi, Yumi& Aiba, Setsuya. 2013. Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease : An Immunohistochemical Investigation. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-451072
Modern Language Association (MLA)
Fujimura, Taku…[et al.]. Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease : An Immunohistochemical Investigation. Clinical and Developmental Immunology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-451072
American Medical Association (AMA)
Fujimura, Taku& Furudate, Sadanori& Kambayashi, Yumi& Aiba, Setsuya. Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease : An Immunohistochemical Investigation. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-451072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451072