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Innate Immune Activation and Subversion of Mammalian Functions by Leishmania Lipophosphoglycan
Joint Authors
Zamboni, Dario S.
Beverley, Stephen M.
Franco, Luis H.
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Leishmania promastigotes express several prominent glycoconjugates, either secreted or anchored to the parasite surface.
Of these lipophosphoglycan (LPG) is the most abundant, and along with other phosphoglycan-bearing molecules, plays important roles in parasite infectivity and pathogenesis in both the sand fly and the mammalian host.
Besides its contribution for parasite survival in the sand fly vector, LPG is important for modulation the host immune responses to favor the establishment of mammalian infection.
This review will summarize the current knowledge regarding the role of LPG in Leishmania infectivity, focusing on the interaction of LPG and innate immune cells and in the subversion of mammalian functions by this molecule.
American Psychological Association (APA)
Franco, Luis H.& Beverley, Stephen M.& Zamboni, Dario S.. 2012. Innate Immune Activation and Subversion of Mammalian Functions by Leishmania Lipophosphoglycan. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-451092
Modern Language Association (MLA)
Franco, Luis H.…[et al.]. Innate Immune Activation and Subversion of Mammalian Functions by Leishmania Lipophosphoglycan. Journal of Parasitology Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-451092
American Medical Association (AMA)
Franco, Luis H.& Beverley, Stephen M.& Zamboni, Dario S.. Innate Immune Activation and Subversion of Mammalian Functions by Leishmania Lipophosphoglycan. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-451092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451092