Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives
Joint Authors
Jubie, Selvaraj
Kalirajan, R.
Sankar, S.
Rafick, M. H. Mohammed
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
A convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a–j was reported.
The compounds were confirmed by physical and analytical data and screened for in vitro antioxidant activity by DPPH method, reducing power assay and total antioxidant capacity method.
The cytotoxic activity of the compounds was also studied in HEp-2 cell line.
The docking studies of the synthesized compounds were performed towards the key nucleoside dsDNA by using AutoDock vina 4.0 programme.
All the isoxazole-substituted compounds have significant activities.
American Psychological Association (APA)
Kalirajan, R.& Rafick, M. H. Mohammed& Sankar, S.& Jubie, Selvaraj. 2012. Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-451103
Modern Language Association (MLA)
Kalirajan, R.…[et al.]. Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-451103
American Medical Association (AMA)
Kalirajan, R.& Rafick, M. H. Mohammed& Sankar, S.& Jubie, Selvaraj. Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-451103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451103