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Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10LtJ and TALLYHOJngJ
Joint Authors
Schultz, David
Leiter, Edward H.
Schile, Andrew
O'Neill, Adam
Reifsnyder, Peter C.
Strobel, Marjorie
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This review compares two novel polygenic mouse models of type 2 diabetes (T2D), TALLYHO/JngJ and NONcNZO10/LtJ, and contrasts both with the well-known C57BLKS/J-Leprdb (db/db) monogenic diabesity model.
We posit that the new polygenic models are more representative of the “garden variety” obesity underlying human T2D in terms of their polygenetic rather than monogenic etiology.
Moreover, the clinical phenotypes in these new models are less extreme, for example, more moderated development of obesity coupled with less extreme endocrine disturbances.
The more progressive development of obesity produces a maturity-onset development of hyperglycemia in contrast to the juvenile-onset diabetes observed in the morbidly obese db/db model.
Unlike the leptin receptor-deficient db/db models with central leptin resistance, the new models develop a progressive peripheral leptin resistance and are able to maintain reproductive function.
Although the T2D pathophysiology in both TALLYHO/JngJ and NONcNZO10/LtJ is remarkably similar, their genetic etiologies are clearly different, underscoring the genetic heterogeneity underlying T2D in humans.
American Psychological Association (APA)
Leiter, Edward H.& Strobel, Marjorie& O'Neill, Adam& Schultz, David& Schile, Andrew& Reifsnyder, Peter C.. 2013. Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10LtJ and TALLYHOJngJ. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-451111
Modern Language Association (MLA)
Leiter, Edward H.…[et al.]. Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10LtJ and TALLYHOJngJ. Journal of Diabetes Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-451111
American Medical Association (AMA)
Leiter, Edward H.& Strobel, Marjorie& O'Neill, Adam& Schultz, David& Schile, Andrew& Reifsnyder, Peter C.. Comparison of Two New Mouse Models of Polygenic Type 2 Diabetes at the Jackson Laboratory, NONcNZO10LtJ and TALLYHOJngJ. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-451111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451111