Decreasing Quality of the New Generations of Anti-Müllerian Hormone Assays
Joint Authors
Liss, Joanna
Sawczak, Miroslaw
Wasniewski, Tomasz
Lukaszuk, Aron
Łukaszuk, Krzysztof
Kunicki, Michał
Wocławek-Potocka, Izabela
Jakiel, Grzegorz
Ludwikowska, Beata
Plociennik, Lukasz
Bialobrzeska, Dorota
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Anti-Müllerian hormone (AMH) measurements are widely used to optimize the stimulation protocols.
First generation AMH kits correlated well with ovarian reserve and response to stimulation.
In the present study we aimed to asses if the new generation kits share the same accurate correlations.
Retrospective data were collected from 8323 blood samples.
For comparison we used Immunotech I generation kit (ImI 4035 samples), Beckman Coulter II generation kit RUO (BCII RUO 3449, samples) and Beckman Coulter II generation kit with IVD certificate (BCII IVD 839 samples).
We compared average AMH concentrations measured with different kits, as well as correlation between kits.
We also compared average AMH concentrations in sera collected on different cycle days and samples of different quality of preservation.
AMH serum concentrations differed for each kit, ranging 4.4 ± 4.12 (mean ± SD) for the ImI, 2.68 ± 3.15 for the BCII RUO, and 1.64 ± 2.85 for BCII IVD.
The mean differences from an adjusted regression model were −48.7%, −40%, and −69.2%, respectively.
In conclusion, the changes of the BC AMH kits are unpredictable; however, the improvement of them is still possible.
It would be very dangerous to use elaborated stimulation protocol (based on the Ist generation AMH results) with the results from the IInd generation assays.
American Psychological Association (APA)
Łukaszuk, Krzysztof& Ludwikowska, Beata& Liss, Joanna& Kunicki, Michał& Sawczak, Miroslaw& Lukaszuk, Aron…[et al.]. 2014. Decreasing Quality of the New Generations of Anti-Müllerian Hormone Assays. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-451113
Modern Language Association (MLA)
Łukaszuk, Krzysztof…[et al.]. Decreasing Quality of the New Generations of Anti-Müllerian Hormone Assays. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-451113
American Medical Association (AMA)
Łukaszuk, Krzysztof& Ludwikowska, Beata& Liss, Joanna& Kunicki, Michał& Sawczak, Miroslaw& Lukaszuk, Aron…[et al.]. Decreasing Quality of the New Generations of Anti-Müllerian Hormone Assays. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-451113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451113