Prevalence of Hepatitis C Virus Genotypes in District Bannu, Khyber Pakhtunkhwa, Pakistan
Joint Authors
Mahmood, Asif
Khan, Nasar
Khan, Sanaullah
Saleha, Shamim
Ullah, Farman
Kamal, Anwar
Source
Hepatitis Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Determination of an individual’s hepatitis C virus (HCV) genotypes prior to antiviral therapy has become increasingly important for the clinical management and prognosis of HCV infection.
Therefore, this study was conducted to investigate the prevalence of HCV genotypes in HCV infected patients of district Bannu in Khyber Pakhtunkhwa region of Pakistan.
Serum samples of 117 seropositive patients were screened for HCV-RNA by using reverse transcriptase-nested polymerase chain reaction (RT-nested PCR) and then PCR positive samples were subjected to HCV genotyping.
Out of 117 seropositive samples, 110 samples were found positive by PCR analysis.
Genotype 3a was the most prevalent one detected in 38% of patients, followed by genotype 3b in 21% of patients, and then genotype 2a in 12% of patients.
However 21% of HCV-PCR positive samples could not be genotyped by method used in this study.
Genotype 3a was the most prevalent genotype in patients of all age groups and its prevalence was found high among patients with increasing age (>34 years).
Moreover, genotypes 3a and 3b were found to be the most prevalent genotypes in patients with history of shaving by barbers, receiving multiple injections, and dental procedures.
In conclusion there is need of further investigation of genotypes of HCV by using more sensitive assays and considering large sample size in district Bannu.
American Psychological Association (APA)
Saleha, Shamim& Kamal, Anwar& Ullah, Farman& Khan, Nasar& Mahmood, Asif& Khan, Sanaullah. 2014. Prevalence of Hepatitis C Virus Genotypes in District Bannu, Khyber Pakhtunkhwa, Pakistan. Hepatitis Research and Treatment،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-451147
Modern Language Association (MLA)
Saleha, Shamim…[et al.]. Prevalence of Hepatitis C Virus Genotypes in District Bannu, Khyber Pakhtunkhwa, Pakistan. Hepatitis Research and Treatment No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-451147
American Medical Association (AMA)
Saleha, Shamim& Kamal, Anwar& Ullah, Farman& Khan, Nasar& Mahmood, Asif& Khan, Sanaullah. Prevalence of Hepatitis C Virus Genotypes in District Bannu, Khyber Pakhtunkhwa, Pakistan. Hepatitis Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-451147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451147